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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HCK All Species: 25.15
Human Site: Y330 Identified Species: 55.33
UniProt: P08631 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08631 NP_002101.2 526 59600 Y330 V V T K E P I Y I I T E F M A
Chimpanzee Pan troglodytes XP_514571 635 71442 Y443 V V T K E P I Y I I T E F M A
Rhesus Macaque Macaca mulatta XP_001087049 602 68092 Y406 V T R E E P I Y I I T E Y M A
Dog Lupus familis XP_542952 627 70167 Y431 V V T E E P I Y I I T E F M A
Cat Felis silvestris
Mouse Mus musculus P08103 524 59111 F328 V V S Q E P I F I V T E F M A
Rat Rattus norvegicus P50545 524 59135 F328 V V S Q E P I F I V T E F M A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514812 514 58948 Y318 V T K E E P I Y I I T E Y M A
Chicken Gallus gallus P42683 508 58121 E316 E P I Y I I T E Y M E K G S L
Frog Xenopus laevis P13406 537 60828 Y339 V V S E E P I Y I V T E Y M S
Zebra Danio Brachydanio rerio XP_698462 1009 113199 Y813 V T K E E P I Y I I T E F M E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9J3 517 59051 I319 V E E P I Y I I T E L M K H G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.3 61.1 76.7 N.A. 89.7 89.5 N.A. 68.8 64 56.6 42 N.A. 52.2 N.A. N.A. N.A.
Protein Similarity: 100 81 72.9 79.9 N.A. 94.8 94.4 N.A. 82.3 78.3 72.4 47.2 N.A. 67.1 N.A. N.A. N.A.
P-Site Identity: 100 100 73.3 93.3 N.A. 73.3 73.3 N.A. 73.3 0 66.6 73.3 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 100 N.A. 100 100 N.A. 86.6 13.3 100 80 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 64 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 10 10 46 82 0 0 10 0 10 10 82 0 0 10 % E
% Phe: 0 0 0 0 0 0 0 19 0 0 0 0 55 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 10 0 19 10 91 10 82 55 0 0 0 0 0 % I
% Lys: 0 0 19 19 0 0 0 0 0 0 0 10 10 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 10 0 82 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 0 10 0 82 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 28 0 0 0 0 0 0 0 0 0 0 10 10 % S
% Thr: 0 28 28 0 0 0 10 0 10 0 82 0 0 0 0 % T
% Val: 91 55 0 0 0 0 0 0 0 28 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 10 0 64 10 0 0 0 28 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _